Noise-induced Cochlear Synaptopathy and Signal Processing Disorders
نویسندگان
چکیده
منابع مشابه
Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
Recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs). Disruption of these synapses not only disables the innervated ANFs but also results in the slow degeneration of spiral ganglion neurons if the synap...
متن کاملNoise-induced cochlear synaptopathy: Past findings and future studies
For decades, we have presumed the death of hair cells and spiral ganglion neurons are the main cause of hearing loss and difficulties understanding speech in noise, but new findings suggest synapse loss may be the key contributor. Specifically, recent preclinical studies suggest that the synapses between inner hair cells and spiral ganglion neurons with low spontaneous rates and high thresholds...
متن کاملNoise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta).
Cochlear synaptopathy can result from various insults, including acoustic trauma, aging, ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in mice can destroy up to ∼50% of synapses between auditory nerve fibers (ANFs) and inner hair cells (IHCs) without affecting outer hair cells (OHCs) or thresholds, because the synaptopathy occurs first in high-threshold A...
متن کاملTranslational issues in cochlear synaptopathy
Understanding the biology of the previously underappreciated sensitivity of cochlear synapses to noise insult, and its clinical consequences, is becoming a mission for a growing number of auditory researchers. In addition, several research groups have become interested in developing therapeutic approaches that can reverse synaptopathy and restore hearing function. One of the major challenges to...
متن کاملNonlinear Cochlear Signal Processing
1 Macromechanics 5 1.1 The early history of cochlear modeling. . . . . . . . . . . . . . . . . . . . . . 6 1.2 The 1 model of the cochlea . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 1.2.1 Impedance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 1.2.2 Thévenin equivalence . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 1.3 2-port analysis . . . . . . . ....
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2019
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2018.09.026